Hair follicle immune privilege and its collapse in alopecia areata
نویسندگان
چکیده
منابع مشابه
Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata
Alopecia areata is considered to be a cell-mediated autoimmune disease, in which autoreactive cytotoxic T cells recognize melanocyte-associated proteins such as tyrosinase. This review discusses recent advances in the understanding of the pathogenesis of alopecia areata, focusing on immunobiology and hormonal aspects of hair follicles (HFs). The HF is a unique "miniorgan" with its own immune an...
متن کاملLymphocytes, neuropeptides, and genes involved in alopecia areata.
Many lessons in autoimmunity - particularly relating to the role of immune privilege and the interplay between genetics and neuroimmunology - can be learned from the study of alopecia areata, the most common cause of inflammation-induced hair loss. Alopecia areata is now understood to represent an organ-restricted, T cell-mediated autoimmune disease of hair follicles. Disease induction is assoc...
متن کاملSuccessful hair transplant of eyebrow alopecia areata.
BACKGROUND Alopecia areata of the eyebrows can be difficult to treat. Intralesional triamcinolone or potent topical steroids are considered the mainstay of medical therapy. This case illustrates the results of an experimental hair transplant to the eyebrows following years of modest response to intralesional triamcinolone. OBJECTIVE The aim of this study was to ascertain the benefits of a hai...
متن کاملAlopecia Areata (AA, Patchy Hair Loss) — Causes and Treatment
Alopecia areata is a non-scarring hair loss disorder that can occur in any part of the body, ranging from a small patch to complete loss of hair, without significant age or sex predisposition. Although the exact etiology is unknown, several patient-specific genetic, immunological, and environmental factors have been implicated. The underlying pathology is probably peribulbar infiltration of CD4...
متن کاملAlopecia Areata (AA, Patchy Hair Loss) — Causes and Treatment
Alopecia areata is a non-scarring hair loss disorder that can occur in any part of the body, ranging from a small patch to complete loss of hair, without significant age or sex predisposition. Although the exact etiology is unknown, several patient-specific genetic, immunological, and environmental factors have been implicated. The underlying pathology is probably peribulbar infiltration of CD4...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2020
ISSN: 0906-6705,1600-0625
DOI: 10.1111/exd.14155